Senior Research Associate – Associate Scientist, Antibody Screening And Display Client uses a combination of novel, cutting edge methods in machine learning, biology at scale and next gen antibody discovery that address key bottlenecks in the drug development pipeline. To accomplish that, we are putting together an incredible team of discovery biologists, computational scientists, and protein scientists who want to make a difference to this important problem. This role will report to the Sr. Scientist heading antibody screening and display, with accountability for supporting mammalian cell culture, high-throughput flow cytometry, and transient transfections.
Key Responsibilities:
Execute high-throughput small-scale protein expression and flow cytometry workflows to characterize antibody samples.
Support antibody screening programs by expressing antibodies in mammalian cells in high-throughput, then staining cell surface markers with high-throughput flow cytometry.
Analyze, interpret, and present expression and flow data to inform antibody selection and optimization decisions.
Independently troubleshoot and optimize experimental protocols for improved throughput, accuracy, and reproducibility.
Maintain meticulous experimental records in electronic lab notebooks and effectively communicate findings in internal meetings.
Qualifications:
B.S in Molecular Biology, Biochemistry, or related life science field with 5+ years of experience, or M.S. with 3+ years of relevant experience.3+ years hands-on experience with flow cytometry is required.
Proficient in mammalian cell culture of adherent and suspension immortalized cell lines, Expi293, HEK293T.Proficient in transient transfections of immortalized cell lines.
Ideal candidates will have prior experience supporting high-throughput antibody discovery workflows with an end goal of identifying novel therapeutic candidates.
Strong organizational and time management skills to contribute to multiple projects in a fast-paced environment.
Experience with electronic lab notebooks (Benchling).Excellent communication skills and ability to document and present experimental results.
Nice-To-Haves:
Experience with automation platforms (liquid handlers) is a strong plus.
Experience with Illumina Next-Generation Sequencing, or 10X sequencing is a strong-plus.
Experience with high-throughput protein purification, Cytiva AKTA, Agilent HPLC, Octet BLI, and/or Carterra SPR is a plus.
Experience with display workflows in mammalian cells, yeast, or phage is a plus.
