Senior Scientist II, Computational Chemistry
scorpion therapeuticsCalifornia (MO)
Senior Scientist II, Computational Chemistry
Posted yesterday
scorpion therapeuticsCalifornia (MO)
Computer and Information Research ScientistsResearch and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
SENIORITY
Senior
About the role
Role: Senior Scientist II in Computational Chemistry leading drug discovery programs within a biopharma focused on RAS-addicted cancers.
Responsibilitiesdesign and execute computational strategies for hit identification and lead optimization, integrate SAR, structural biology, and ADME/PK data to inform compound prioritization, develop virtual screening workflows, evaluate advanced computational methods including physics-based modeling and AI/ML, and collaborate across multidisciplinary teams to accelerate therapeutic development.
Requirements:
Ph. D. in computational chemistry or related field;
5+ years industry experience with impactful contributions to drug discovery, including publications and patents;
expertise in protein-ligand analysis, molecular modeling, MD simulations, QM calculations, and relevant software;
proficiency in programming languages such as Python, Bash, or R;
excellent communication skills.
Preferredexperience with challenging modalities like macrocycles, molecular glues, covalent ligands, HPC/cloud environments, and a strong publication record.
High-Value Oncology focus, RAS pathway, small molecules, early to late-stage (preclinical to clinical), computational drug design, interdisciplinary collaboration.
Work Setup: Not specified.
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