Research Associate / Senior Research Associate – Oligonucleotide Chemistry

Location: San Diego, CA — Onsite

Employment Type: Full-time

Department: Oligonucleotide Chemistry About OliXOliX Pharmaceuticals develops next-generation RNA interference (RNAi) therapeutics. Our San Diego team at OliX US supports the discovery and development of innovative nucleic acid-based medicines.

Role Summary: We are seeking a Research Associate or Senior Research Associate to support the synthesis, purification, analytical characterization, and conjugation of chemically modified oligonucleotides for research and preclinical programs. Responsibilities and title will reflect the candidate’s experience and demonstrated technical capabilities. Research Associates will receive hands-on training and scientific guidance. Senior Research Associates will independently execute assigned workflows, troubleshoot technical issues, contribute to method improvements, and help train junior colleagues.

Key Responsibilities: Perform solid-phase oligonucleotide synthesis, cleavage, deprotection, purification, desalting, and sample processing. Conduct analytical characterization using UHPLC, LC–MS, UV–Vis spectroscopy, and related techniques. Perform oligonucleotide purification using preparative HPLC and medium-pressure liquid chromatography (MPLC).Support oligonucleotide conjugation and downstream processing, including buffer exchange, concentration, and ultrafiltration/TFF, as needed. Prepare reagents, buffers, solutions, and materials for laboratory experiments. Operate, clean, and maintain laboratory instruments; troubleshoot technical issues appropriate to experience level. Maintain accurate experimental records, sample tracking, and data summaries. Assist with preparing and revising SOPs, laboratory methods, and technical documentation. Collaborate with chemistry and biology teams to meet material requirements and project timelines. Maintain chemical, consumable, and sample inventories and follow established laboratory safety procedures. Additional expectations for Senior Research Associates: Independently plan and execute assigned experiments and workflows in consultation with scientists. Troubleshoot synthesis, purification, analytical, and instrumentation issues. Design and evaluate method improvements to increase product quality, yield, reproducibility, and throughput. Interpret experimental results, recommend next steps, and communicate findings to the team. Draft SOPs and technical summaries and provide hands-on training to junior colleagues.

Required: All Candidates Bachelor’s degree in Chemistry, Biochemistry, Chemical Biology, Chemical Engineering, Pharmaceutical Sciences, or a related scientific discipline. Hands-on laboratory experience and a foundation in chemistry or biochemistry. Strong attention to detail and ability to maintain accurate experimental records. Good written and verbal communication skills. Ability to organize assigned work and collaborate effectively in a laboratory team. Research Associate Typically 0–2 years of relevant laboratory experience; academic research, internships, or industry experience may qualify. Demonstrated laboratory aptitude and willingness to learn new techniques and instrumentation. Ability to follow established procedures and troubleshoot basic issues with guidance. Direct oligonucleotide industry experience is preferred but not required. Training will be provided to qualified candidates. Senior Research Associate Typically 3–5 years of relevant laboratory experience, or an equivalent combination of education and experience. Demonstrated ability to independently execute relevant synthesis, purification, or analytical workflows. Practical experience operating and troubleshooting chromatography systems or other relevant laboratory instruments. Ability to interpret experimental data and contribute to method development or optimization. Experience preparing technical documentation and supporting the training of colleagues. Direct oligonucleotide experience is strongly preferred. Candidates with relevant peptide, nucleic acid, or small-molecule chemistry experience will also be considered.

Preferred: Either Level Experience with chemically modified oligonucleotides or solid-phase synthesis. Experience with preparative HPLC, UHPLC, LC–MS, or other purification and analytical techniques. Familiarity with bioconjugation, ultrafiltration/TFF, or related processing methods. Experience in a biotechnology, pharmaceutical, or academic research laboratory. Familiarity with SOPs and practices that support data integrity and traceability. Why Join OliX?Join a collaborative team and contribute directly to the development of RNA therapeutics while expanding your expertise in oligonucleotide chemistry, analytical characterization, and process development. OliX US offers: Competitive base salary. Medical, dental, and vision insurance.401(k) retirement plan. Long-term disability insurance. Stock option opportunities, subject to eligibility and company plan terms. Paid holidays and company time off. Paid year-end company shutdown. Eligible employees may receive wage-replacement benefits for parental bonding and pregnancy-related disability through California’s Paid Family Leave and State Disability Insurance programs. Opportunities for professional growth and technical training. Compensation Research Associate: $58,000–$80,000 annually. Senior Research Associate: $80,000–$100,000 annually. Title and compensation will reflect the candidate’s education, relevant experience, technical expertise, and demonstrated ability to perform the responsibilities of the role. OliX US is an equal opportunity employer committed to an inclusive workplace.