Translational Medicine, Associate Scientist I

Required Experience and Skills: Experience with LC-MS technologies. Experience with maintaining and troubleshooting HPLC and mass spectrometers. Demonstrated hands-on experience in protein/peptide identification, quantitation and characterization using mass spectrometers. Highly motivated, self-driven and results-oriented individual with excellent communication skills. An excellent team player that can closely collaborate with internal and external collaborators. The successful candidate should be an experienced scientist with knowledge and hands on experience in quantitative/qualitative mass spec analysis of protein/peptide and/or small molecule entities. Hands on experience with bioanalytical technologies a plus.

Preferred Experience and Skills: Previous experience in automation instruments such as Assaymap and Hamilton is a plus. Previous experience with Watson LIMS, Sciex Triple Quads and MultiQuant is a plus but not required. Previous experience in drug discovery and development is a plus but not required. High learning agility and a willingness to contribute to all levels within the DMPK group. Comfortable with risk taking and undertaking hypothesis-driven experimentation.

Responsibilities: The Pharmacokinetics, Dynamics, Metabolism and Bioanalytic (PDMB) function of MRL South San Francisco is seeking a dynamic and collaborative scientist for the Drug Metabolism and Pharmacokinetics (DMPK) group. The Translational Medicine, Associate Scientist II will be a member of the function providing expertise as a key component of the multi-disciplinary drug discovery effort in MRL South San Francisco, with a focus on supporting preclinical development of therapeutics of various modalities through integrated understanding of drug disposition and pharmacology. Therapeutic areas may include immunology and oncology, cardiovascular and metabolic disease, and ophthalmology.

• The Translational Medicine, Associate Scientist II will be a member of the DMPK function providing expertise as a key component of the multi-disciplinary drug discovery effort in MRL South San Francisco, with a focus on supporting preclinical development of next generation biologics, antibody drug conjugates (Client), and small molecule using liquid chromatography-mass spectrometry (LC-MS) technologies.
• The scientist will contribute to the biotransformation investigation of next gen biologics and Antibody Drug Conjugate (Client) using liquid chromatography-mass spectrometry (LC-MS).
• The candidate will also contribute to small molecule bioanalysis of in vivo PK samples.
• Ideal candidate is expected to support the in vitro and in vivo biotransformation study via sample preparation and LC-MS analysis, support the bioanalysis of small molecule in PK study, and supervise LC-MS lab operations including lab housekeeping, instrument maintenance and troubleshooting.