Senior Mass Spectrometry Platform Lead

Posted today

insight globalUpper Providence Twp (PA)

Natural Sciences Managers Research and Development in Biotechnology (except Nanobiotechnology)

SENIORITY

Lead

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About the role

Required Skills & Experience: Masters or PhD in Analytical Chemistry, Biochemistry, Protein Sciences, Mass Spectrometry, Structural Biology, or related scientific discipline.-8+ years of industry experience in mass spectrometry and protein characterization.-Experience supporting biologics, antibodies, protein therapeutics, or discovery programs.-Experience with Mass Spectrometry Platforms-Thermo Orbitrap Systems-Thermo Q Exactive Platforms-Agilent LC/TOF-MS Systems-LC-MS/MS Technologies

Nice to Have:

Skills & ExperienceHDX-MS experience
Cross-linking MS experience
Epitope mapping studies

Job Description: We are seeking a highly experienced Mass Spectrometry Platform Lead to oversee the operation, optimization, and scientific advancement of a four-instrument mass spectrometry platform supporting multiple projects. The successful candidate will provide platform leadership, protein characterization expertise, workflow development, user training, and scientific support for antibody discovery, protein engineering, and therapeutic development programs.

Key Responsibilities:

Manage daily operation of a multi-instrument mass spectrometry platform
Maintain instrument uptime, performance qualification, calibration, and maintenance schedules
Execute protein characterization studies utilizing peptide mapping, intact mass, PTM analysis, and native mass spectrometry
Develop standardized workflows, SOPs, and QC benchmarks
Process, analyze, interpret, and report analytical data
Train scientific users on instrumentation and workflows
Support protein reagent characterization including antibodies, antigens, scFvs, minibinders, and ADCsLead workflow optimization efforts to improve turnaround time and throughput
Maintain documentation within electronic laboratory notebooks and data repositories
Support advanced structural MS studies including HDX-MS and crosslinking experiments

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