Scientist, Synthetic Biology New Boston, Massachusetts

Posted yesterday

strand therapeuticsEast Boston (MA)

Molecular and Cellular Biologists Research and Development in Biotechnology (except Nanobiotechnology)

SENIORITY

Lead

SALARY

$120,000 per year

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About the role

Strand Therapeutics is a clinical-stage biotechnology company pioneering programmable mRNA therapeutics to unlock the full potential of genetic medicines. Strand is applying its proprietary Signal Stack platform, which integrates EverScript circular RNA, AmpliScript self-replicating RNA, SignalPath targeted delivery, and logic-driven SignalLock genetic circuits to enable precise control of therapeutic activity across tissues and cell types and overcome foundational limitations in targeting, durability, and safety. Strand is advancing a pipeline with an initial focus on oncology and autoimmune disease. Its initial program, STX-001, an intratumorally delivered LNP-encapsulated self-replicating RNA expressing IL-12, has demonstrated preliminary evidence of systemic immune activation and anti-tumor activity in patients with advanced solid tumors who have progressed on prior therapies. Building on this early clinical validation, intravenously delivered STX-003 is designed for tumor-targeted expression and avoidance of off-target expression. STX-003, which is expected to enter the clinic in mid-2026, has the potential to be a major step forward for the fields of genetic medicine and oncology. Strand is also advancing STX-005, an in vivoCAR-T program designed to enable controlled, durable expression and repeat dosing. Founded by MIT synthetic biology pioneers, Strand has raised over $250 million and is headquartered in Boston, MA.Become the next standout single strand!

Job Summary: We are looking for a highly motivated and innovative candidate for the role of Scientist of Synthetic Biology. The ideal candidate will use fundamental biological design principles to build RNA-based genetic circuits to facilitate drug discovery and development. This is a fantastic opportunity to make a significant impact as a scientifically motivated self-starter capable of independently conceiving, conducting, and critically analyzing their own work with minimal supervision.

Primary Responsibilities:

Design and develop synthetic genetic constructs to enable programmable, cell-type specific gene expression.
Build and test engineered circuits for desirable phenotypes in relevant cell systems in vitro thus validating predicted designs.
Plan experiments utilizing molecular techniques including molecular cloning, mammalian cell transfection, flow cytometry, ELISA, qPCR, Western blot etc.
Maintain proper records in electronic notebook and contribute to writing protocols
Communicate experimental methods and results to fellow team members and work closely with cross-functional teams.

Qualifications: PhD in Biomedical Engineering, Boinformatics, or requivalent required.1-2 years of professional research experience in industrial and/or academia required. Ability to plan, design and execute experiments as part of a project, communicate findings to a diverse audience, and iterate on ideas for optimizing genetic circuit designs for a desired behavior. Experience with cellular and molecular biology techniques like molecular cloning, qPCR, mammalian cell culture, and transfection required. Prior experience with flow cytometry, image analysis, and automation equipment is a plus. Hands-on experience with in vitro transcription of mRNA required. Ability to quickly adapt to change and thrive in a dynamic and entrepreneurial early-stage environment. A strong team player with excellent oral and written communication skills and a demonstrated ability to work independently. Independently motivated, detail oriented and good problem-solving ability. Excellent organizational skills and attention to detail. Strand offers a fast-paced, entrepreneurial, team-focused small company environment. We also offer a top-notch benefits package (health, dental, life, open PTO, onsite lunch catering, commuter support and more) and work/life flexibility and integration. Being part of the Strand team allows you to become part of a small team that supports professional development while working together to meet Strand’s goals. Strand Therapeutics is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law. Strand does not accept unsolicited resumes from any source other than directly from candidates.

Job Type: Full-time

Salary: $120,000 - $132,000 annually plus bonus and equity incentives

Pay Transparency Base Salary Range$120,000 - $132,000 USDU.S. Standard Demographic Questions We invite applicants to share their demographic background. If you choose to complete this survey, your responses may be used to identify areas of improvement in our hiring process. How would you describe your gender identity? (mark all that apply) Select...How would you describe your racial/ethnic background? (mark all that apply) Select...How would you describe your sexual orientation? (mark all that apply) Select...Do you identify as transgender? Select...Do you have a disability or chronic condition (physical, visual, auditory, cognitive, mental, emotional, or other) that substantially limits one or more of your major life activities, including mobility, communication (seeing, hearing, speaking), and learning? Select...Are you a veteran or active member of the United States Armed Forces? Select...Voluntary Self-Identification For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiringprocess or thereafter. Any information that you do provide will be recorded and maintained in aconfidential file. As set forth in Strand Therapeutics’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law. If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measurethe effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categoriesis as follows: A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability. A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service. An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval, or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense. An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.Select...By checking this box, I consent to Strand Therapeutics collecting, storing, and processing my responses to the demographic data surveys above.

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