Principal, Biostatistician, Roivant Health

Posted 16 days ago

roivant sciences pennsylvania us new york city ny usNew Kingstown (PA)

Biostatisticians Research and Development in Biotechnology (except Nanobiotechnology)

SENIORITY

Lead

SALARY

$130,000 to $220,000 per year

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About the role

Principal, Biostatistician, Roivant Health Roivant aims to improve health by rapidly delivering innovative medicines and technologies to patients. We do this by building Vants – nimble, entrepreneurial biotech and healthcare technology companies with a unique approach to sourcing talent, aligning incentives, and deploying technology. Roivant Health is Roivant's platform for the creation of new technology Vants, focused on delivering improvements to human health outside of our traditional biotech platform. In six years since inception, we've created eight enduring companies and over $1B in enterprise value, including the leading deidentified healthcare data exchange platform (Datavant) and a top-tier computational drug discovery company (VantAI) which has partnered with Johnson & Johnson, Bristol-Myers Squibb, and Boehringer Ingelheim. Our goal is to improve human health by rapidly discovering, developing and delivering innovative medicines and technologies to all patients. Our success is predicated on attracting and retaining top talent, generating new ideas and promoting an open and collaborative culture. We embrace diversity across all dimensions and levels of the organization, and we strive to ensure every employee is supported in reaching their full potential. We hire motivated people with diverse backgrounds, identities, experiences and skillsets. We are committed to fostering an inclusive culture where all employees feel valued, respected and empowered to create value for patients.

Position Summary: The Principal, Biostatistician will own the statistical and quantitative work that connects clinical evidence to the most important decisions Roivant makes across its pipeline. This is not a strategy role — this is a figure-things-out and get-things-done role in a high-stakes environment with substantial ownership. We expect you to get to ground truth on the hardest clinical and scientific questions the company faces, working directly in trial datasets and translating rigorous analysis into recommendations that leadership acts on. The Principal will pressure-test the clinical assumptions underpinning key pipeline and commercial decisions, build the statistical frameworks needed to evaluate evidence across assets, and ensure Roivant has a clear-eyed view of what its data shows. The scope is intentionally broad and is well-suited to a high-potential individual earlier in their career with exceptional upside and a strong desire to take on responsibility.

Responsibilities:

Clinical Trial Data & Signal Detection
Work directly in ongoing and completed clinical trial datasets (CSRs, patient-level data, interim readouts) to identify efficacy signals, safety patterns, and subgroup effects that inform go/no-go and commercialization decisions
Build rigorous statistical analyses from scratch: mixed-effects models, longitudinal models, Bayesian frameworks, subgroup analyses, and sensitivity analyses across Roivant's pipeline assets
Monitor emerging safety signals and unexpected findings in real time across ongoing studies; surface and contextualize them for leadership before they become surprises
Pressure-test clinical assumptions: challenge endpoint choices, scrutinize statistical analysis plans, and flag where the data does not support the narrative
Execute focused 1-5 day analytical sprints on the highest-priority questions from Roivant and Vant leadership
Evidence Synthesis & Competitive Intelligence
Develop a deep, differentiated read of the clinical evidence base for Roivant's near-commercial assets: what the data shows, what it does not, and where the science is genuinely uncertain
Analyze competitors' trial data, published and unpublished, with the same rigor applied to Roivant's own: endpoints, patient populations, effect sizes, and durability
Synthesize findings from literature, registries, claims, and proprietary datasets into coherent evidence narratives that hold up under scrutiny
Data Infrastructure & Cross-Platform WorkDrive selection and integration of the data sources needed to support portfolio decisions, including claims, labs, clinical trial data, and genomics
Help build shared analytical infrastructure across Roivant and Vant companies
Identify opportunities to apply consistent statistical frameworks across assets and therapeutic areas

Qualifications:

Advanced degree in biostatistics, statistics, epidemiology, or a closely related quantitative field; direct experience in clinical trial statistics strongly preferred
Hands-on fluency with clinical trial data; you have worked directly in patient-level datasets, not just read summaries of analyses others ran
Deep command of statistical methods used in clinical development: mixed-effects models, longitudinal and repeated-measures analyses, Bayesian approaches, multiplicity adjustment, and sensitivity analyses
Familiarity with clinical trial design and regulatory statistical frameworks (ICH E9, estimands, SAP development)
Track record of translating rigorous analysis into decisions; your numbers have changed something
Able to present complex statistical findings clearly to non-technical audiences, including CEO-level stakeholders
Intensely curious, resourceful, and motivated; you run toward hard, ambiguous problems

Roivant is preparing to become the next breakout commercial-stage biotech, with the commercialization of brepocitinib, IMVT-1402, and mosliciguat. Getting those launches right requires an unusually rigorous understanding of the clinical evidence that defines each market: what the data actually shows, not what anyone wishes it showed. This role ensures that understanding exists. It carries real ownership, direct exposure to senior leadership, and a trajectory that can serve as a foundation for future senior roles across the platform.

Compensation & Benefits: This is a full-time position. The role offers meaningful equity participation and a comprehensive company-sponsored benefits package. Base salary will be determined during the interview process and will vary based on multiple factors, including prior experience, relevant expertise, current business needs, and market conditions. The expected base salary will generally be between $130,000 to $220,000 per year at commencement of employment, but the final salary offered may be outside this range based on individual circumstances. Roivant Sciences provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.

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