Associate Scientist, mRNA Platform Analytical Development

Posted 19 days ago

omni inclusiveSeattle (WA)

Molecular and Cellular Biologists Research and Development in Biotechnology (except Nanobiotechnology)

SENIORITY

Senior

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About the role

Associate Scientist, mRNA Platform Analytical Development

Location: Seattle, WA * 100% OnsiteTop Skills:

Proficiency in generating and interpreting qPCR and RT-PCR data setsProficiency with capillary electrophoresis (preferred Sciex PA800 Plus system), Agarose gel electrophoresis, and/or TapeStation analysisProficiency with ELISA workflowsExperience working with, storing, and analyzing purified nucleic acids We are seeking a highly motivated Associate Scientist to work in a fast-paced P&AD environment applying rigorous scientific principles towards developing a platform process for producing mRNA. As a part of the Gene Delivery and Editing Process Development (GDEPD) organization, the ideal Associate will possess sufficient experience in analytical method development of biological molecules, with a high preference for any experience with developing analytical methods for measuring mRNA impurities, quality attributes, and expression in cells. A successful Associate will directly employ biophysical, analytical, and cell assay techniques to develop our next-generation gene edited therapies. In this capacity, the Associate will design and execute analytical methods for mRNA molecules to enable robust ex vivo studies. An outstanding candidate will be driven by a desire to create, optimize, and define processes with speed in a collaborative environment.

Key Responsibilities:

Execute and troubleshoot analytical assays for the characterization of mRNA molecules
Assist in the design, and evaluate the performance, of new analytical development assays
Assist in establishing SOPs and protocols for analytical assays
Manage samples and data related to mRNA platform process development
Optimize workflows for assessing mRNA attributes and impurities
Provide experimental design and executional support to team members in adjacent and related functions (e.g. clinical development programs, high throughput process development, etc.)Actively participate and support lab maintenance and continuous improvement initiatives
Maintain accurate and detailed laboratory notebook and documentation
Summarize and present data in group meetings and contribute to group discussions
Author technical reports, study memos, and protocols

Basic Qualifications: STEM degree with 2+ years of relevant industry experience; title/compensation will be commensurate with education, experience, and skillset Proficiency in generating and interpreting qPCR and RT-PCR data setsProficiency with capillary electrophoresis (preferred Sciex PA800 Plus system), Agarose gel electrophoresis, and/or TapeStation analysisProficiency with ELISA workflowsExperience working with, storing, and analyzing purified nucleic acids Independently motivated with the ability to work in teams Ability to communicate clearly and concisely through oral presentation and technical writing Ability to leverage literature, internal and external resources to solve problems and develop new technologies Possess a growth mindset and the ability to thrive in a fast-paced, highly collaborative environment

Preferred Qualifications:

Degree in biological or chemical engineering, biochemistry, or bio-related field
Experience with IP-RP-UPLC method development
Experience with JMP for DoE design and analysis
Experience with the in vitro transcription of mRNAExperience interacting and collaborating with vendors
Experience with collecting, organizing, and interpreting large data sets
Experience with mammalian cell-based assays which include flow cytometric readouts

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