Senior Scientist, Bioanalytical Development

Posted 19 days ago

protagonist therapeuticsNewark (CA)

Medical Scientists, Except Epidemiologists Research and Development in Biotechnology (except Nanobiotechnology)

SENIORITY

Senior

SALARY

$140,000 and $160,000/year

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About the role

Position: Senior Scientist, Bioanalytical Development

Location: Newark, CA

Job Id: 427# of Openings:0Senior Scientist, Bioanalytical Development

About Us: Protagonist Therapeutics is a biopharmaceutical company built on a proprietary peptide technology platform that has now produced two FDA-approved, first-in-class medicines, generating royalties and milestones from global commercial partnerships with Johnson and Johnson and Takeda Pharmaceutical Company Limited. ICOTYDE (icotrokinra), licensed to Johnson & Johnson company Janssen Biotech, Inc., is the first and only targeted oral peptide that precisely blocks the Interleukin-23 receptor. ICOTYDE was launched in the U.S. in March 2026 for the treatment of moderate-to-severe plaque psoriasis in adults and pediatric patients 12 years of age or older and is in Phase 3 development for psoriatic arthritis, ulcerative colitis and Crohn's disease. ICOTYDE was jointly discovered by Protagonist and Johnson & Johnson scientists, with Protagonist having primary responsibility for the development of ICOTYDE through Phase 1, and Johnson & Johnson assuming responsibility for further clinical and regulatory development and commercialization. Protagonist also discovered and led research and development through Phase 3 for MIMRYLO (rusfertide), a first-in-class hepcidin mimetic peptide licensed to Takeda Pharmaceutical Company Limited for worldwide commercialization. MIMRYLO is approved in the U.S. for the treatment of erythrocytosis in adults with PV. The Company also has a number of clinical and preclinical programs based on clinically and commercially validated targets and addressing unmet medical needs, including an oral IL-17 antagonist peptide, anti-obesity dual and triple agonists, an oral hepcidin functional mimetic, and the recently announced IL-4 and amylin discovery programs. More information on Protagonist, its pipeline drug candidates, and clinical studies can be found on the Company's website at .

Position Summary: We are seeking a Senior Scientist in the Bioanalytical department. The qualified candidate will be a critical member of the group and work closely with our established team developing and optimizing analytical methods and performing bioanalytical work to screen chemical entities for new drug candidates. This is an exceptional opportunity to work with a core discovery group within a successful biopharmaceutical company and bring drugs from ideas to the clinic. We are committed to a thriving in-office culture. This role requires being on-site at our office in Newark, CA 4 days a week.

Responsibilities:

Operate and maintain analytical instrumentation such as HPLC, mass spectrometer, and other lab equipment
Prepare reagents, calibration standards, QCs and standard curves, and samples for analysis
Perform, optimize, develop, and execute new and existing analytical methods
Perform analytical assays (i.e., ELISA) to support PD and efficacy studies
Work with Bioanalytical team to ensure adequate supplies of consumables and reagents
Possess technical and scientific understanding of bioanalytical assays and experimental design to support the development
Keep excellent experimental records
Effectively communicate results to the Bioanalytical team and cross-functionally

Follow and maintain laboratory safety protocol and health-conscious environment in the workplace. Required

Skills & Qualifications:

MS in chemistry, analytical chemistry, biochemistry, bioengineering, or related fields with 5+ years of relevant industry or academic experience or BS with 10+ years of experience.
Previous experience operating and maintaining analytical instrumentation, including HPLC, mass spectrometer, spectrophotometers, and data analysis software
Understanding and experience with the fundamentals of chromatography and analytical separations
Proven ability to follow SOPs and optimize existing methods
Time management and organizational skills with attention to detail
Thrive in a fluid, dynamic, and fast-paced environment
Able to collaborate effectively within multi-disciplinary teams
Effectively communicate results to the Bioanalytical team, across various functional areas, and project team
Pay Range The base pay range for this position at commencement of employment is expected to be between $140,000 and $160,000/year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience.

Benefits:

A top priority for Protagonist Therapeutics, Inc. is to provide a robust and comprehensive health and wellness program for our employees and their families. We offer a variety of high-quality coverage and benefit options.
Health Care benefits. Protagonist covers 100% of the premium cost for medical, dental, and vision coverage for all full-time employees and their dependents.
Flexible Spending Accounts – Healthcare FSA, Dependent Care FSA, Commuter Benefits 401(k) Plan
Flexible Vacation PolicyLife Insurance (Basic, Voluntary & AD&D)
Short Term & Long Term Disability
Company paid lunch and snacks
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