Staff Bioinformatics Scientist
virtual vocationsDenver (CO)
Staff Bioinformatics Scientist
Posted today
virtual vocationsDenver (CO)
SENIORITY
Lead
About the role
Bridging the gap between genomic variants and clinical applications, the full-time Staff Bioinformatics Scientist will design automated approaches for variant annotation, integrate AI/ML techniques into production pipelines, and monitor the performance of these systems while working remotely.
Key responsibilities:
Design and prototype automated methods for the annotation and classification of germline variants
Evaluate and integrate AI/ML approaches for evidence extraction and disease-to-gene mapping into production workflows
Lead analytical validation studies to ensure compliance with CLIA/CAP standards and support LDT filings
Required qualifications:
Ph.D. in Bioinformatics, Computational Biology, Human Genetics, or a related field with 5+ years of clinical genomics experience
Deep expertise in human molecular genetics and ACMG/AMP variant interpretation guidelines
Advanced proficiency in genetic file formats, particularly VCF, and data science tools such as SQL and Python
Demonstrated ability to evaluate emerging technical approaches for feasibility and impact
Strong judgment in assessing AI-generated analyses for scientific validity and regulatory compliance
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