Principal Scientist - Oligonucleotide Discovery Chemistry

Posted yesterday

gskSomerville (MA)

Chemists Research and Development in Biotechnology (except Nanobiotechnology)

SENIORITY

Lead

Apply

About the role

GSK in Cambridge, MA is seeking a PhD-level chemist to help establish pre‑clinical oligonucleotide conjugation capabilities for ASOs, siRNA, SSO, and RNA editors with small molecules, lipids, and linkers. The role covers method development from milligram to gram scale and requires leadership in cross‑functional settings. You will design workflows, draft SOPs, and work with analytical teams to ensure high-quality conjugates while collaborating across teams to meet program milestones.

Before you apply

Applying takes about a minute. These four things decide how fast it moves after that.

Your profile is current

It's what we read first. Occupations, seniority and locations matter more than a long history.

Two examples you can talk through

Not a portfolio — just two pieces of work where you can explain the decisions and what you'd change.

A number in mind

What you're on now and what would make you move. We negotiate better when we know both.

Your notice period

Employers plan around it, and it's the question that stalls offers most often.

Once you apply, someone reads it and calls you before anything reaches the employer — usually within two working days.