Research Scientist

Posted 10 days ago

california institute of technologyPasadena (CA)

Molecular and Cellular Biologists Research and Development in Biotechnology (except Nanobiotechnology)

SENIORITY

Senior

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About the role

Caltech is a world-renowned science and engineering institute that marshals some of the world's brightest minds and most innovative tools to address fundamental scientific questions. We thrive on finding and cultivating talented people who are passionate about what they do. Join us and be a part of the diverse Caltech community.

Job Summary: We are seeking a motivated biochemist and structural biologist to join the Bjorkman Lab as a Research Scientist. The successful candidate will lead efforts to design and evaluate pan-coronavirus immunogens and use structural biology to aid in our understanding of immune responses. The biochemist will perform scientific research aimed at designing immunogens to elicit broad responses to coronaviruses and structurally characterizing antibodies and antigens. They will work directly with the PI on designs and modifications to experimental techniques and procedures.

Essential Job Duties: Characterize designed immunogens structurally and functionally, including expression and purification, binding studies, and structural studies. Perform animal immunization experiments to evaluate the immunogenicity of designed immunogens. Evaluate the immune response for binding, neutralization, and specificity. Perform research to determine the structural basis of immune recognition of antigens, including assessing binding of antibodies to immunogens and solving and analyzing antibody-antigen structures. Will organize and conduct experiments to study and investigate scientific problems. Work directly with PI, other lab members and collaborators on designing experiments, analyzing results, and writing scientific papers. Research work will be presented at seminars and conferences applicable to structural biology field; the candidate will participate in lab discussions and group meetings.

Basic Qualifications: Ph. D. in Biology, Chemistry, or related field. Minimum of 5 years of post-doctoral and/or biotech experience, including protein biochemistry, protein expression, purification, and characterization. Minimum of 5 years of relevant experience in structural biology (Single-particle cryo-electron microscopy and/or X-ray crystallography).Minimum of 5 years of experience in vaccine design or evaluation in animals models. Must be able to develop solutions to complex problems that require the regular use of ingenuity, creativity, and analysis of situations or data that require and in-depth evaluation of criteria for obtaining results. Strong interpersonal, organizational, and leadership/mentoring skills.

Required: DocumentsResume.

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