Macrocycle Chemistry Director - Hit-to-Lead Leader

Posted yesterday

eli lilly companyIndianapolis (IN)

Medical Scientists, Except Epidemiologists All Other Basic Organic Chemical Manufacturing

SENIORITY

Manager

Apply

About the role

Eli Lilly and Company is seeking a Senior Research Scientist with a strong background in macrocyclic chemistry to join Early Molecule Design (EMD) in Indianapolis, Indiana. You will lead hit-finding and hit-to-lead efforts for a synthetic macrocycle platform, leveraging SAR and ADME/DMPK expertise to advance orally bioavailable compounds. The role spans collaboration across multinational teams, guiding design strategies, documenting findings, and mentoring junior scientists.

Before you apply

Applying takes about a minute. These four things decide how fast it moves after that.

Your profile is current

It's what we read first. Occupations, seniority and locations matter more than a long history.

Two examples you can talk through

Not a portfolio — just two pieces of work where you can explain the decisions and what you'd change.

A number in mind

What you're on now and what would make you move. We negotiate better when we know both.

Your notice period

Employers plan around it, and it's the question that stalls offers most often.

Once you apply, someone reads it and calls you before anything reaches the employer — usually within two working days.