Lipid Nanoparticle Formulation Senior Scientist to Associate Director

Posted today

newcoSan Diego (CA)

Molecular and Cellular Biologists Research and Development in Biotechnology (except Nanobiotechnology)

SENIORITY

Lead

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About the role

Company Description: We are a privately held, stealth mode start-up biotechnology company developing lipid nanoparticle-based approaches to address unmet medical needs.

The role: We are seeking an experienced hands-on and strategic Lipid Nanoparticle (LNP) Formulation Scientist to drive the design, execution, and analysis of Design of Experiments (DOE) to establish cutting-edge next-generation LNP platforms focusing on different disease areas. This role will play a critical part in developing, optimizing, and characterizing LNP systems for nucleic acid delivery in a fast-paced, collaborative research environment.

Key responsibilities:

Design, execute, and analyze DOE-based formulation experiments to develop and optimize novel LNP formulations
Lead formulation innovation efforts, including lipid selection, composition optimization, and novel process development
Perform LNP screening and characterization, including size, PDI, encapsulation efficiency, stability, and performance metrics
Lead formulation process scale-up and technology transfer as needed
Collaborate closely with cross-functional teams (biology, analytics, chemistry, and project management) to advance programs
Maintain thorough experimental documentation and clearly communicate results and recommendations to stakeholders
Contribute to troubleshooting formulation challenges and continuously improve experimental workflows Professional experience and qualifications •Senior Scientist, PhD in Chemical Engineering, Bioengineering, Pharmaceutical Sciences, Chemistry, Biology, or related field with 3-5 years relevant experience; •Principal Scientist or Associate Director, PhD in Chemical Engineering, Bioengineering, Pharmaceutical Sciences, Chemistry, Biology, or related field with 6+ years relevant experience
Strong hands-on experience with LNP formulations, including formulation development and optimization, process development and scaling-up
Demonstrated expertise in DOE methodologies and statistical experimental design
Extensive experience with LNP screening and analytical techniques
Deep understanding of lipid-based delivery systems and formulation science principles
Proven ability to work effectively in a team-oriented, fast-paced environment
Strong problem-solving skills and ability to manage multiple priorities simultaneously
Strong communication skills for presenting data and influencing technical decisions

What We Offer:

Opportunity to work at the forefront of LNP formulation innovation
Collaborative, science-driven culture with high impact research
Competitive compensation and benefits package, including health, dental, vision, and life insurance
401(k) with company match

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