Post Doctoral Scholar - Pathology

Position Summary: We are seeking a highly motivated Post Doctoral Scholar to investigate the immunopathogenesis of systemic lupus erythematosus (SLE), lupus nephritis, and rheumatoid arthritis (RA) through the integrated study of immune cell function and RNA regulatory mechanisms. The successful candidate will combine advanced immunological approaches with genomic and computational analyses to identify RNA-mediated pathways that drive immune dysregulation, kidney inflammation, and tissue injury in autoimmune disease.

Responsibilities: Investigate the roles of T cells and dendritic cells in SLE, lupus nephritis, and RA Define disease-associated immune cell states and molecular pathways using transcriptomic, epigenomic, and spatial omics approaches Integrate computational and experimental approaches to uncover biologically actionable mechanisms and therapeutic targets Identify RNA regulatory networks and RNA-binding protein–mediated mechanisms that control immune cell activation, differentiation, and pathogenic function Perform multi-parameter flow cytometry, intracellular cytokine staining, ELISAs, and T cell–dendritic cell co-culture assays Execute murine autoimmune disease models Assess disease outcomes including proteinuria, renal pathology, joint inflammation, autoantibody production, and immune cell phenotypes Publish findings in high-impact journals, present at scientific meetings, mentor trainees, and contribute to grant applications

Job Requirements: Ph.D., M.D., or M.D./Ph.D. in Immunology, Molecular Biology, Genetics, Computational Biology, Bioinformatics, or a related field Strong background in immunology, including T cell biology and dendritic cell biology Experience with transcriptomic data analysis, including bulk RNA-seq and/or single-cell RNA-seq Demonstrated research productivity with peer-reviewed publications in immunology, RNA biology, genomics, or autoimmune disease Experience with multi-color flow cytometry, immune phenotyping, and FlowJo analysis Proficiency in immunological assays

Additional Information Location: Tzagournis Medical Research Facility (0163)

Position Type: Term (Fixed Term)

Scheduled Hours: 40

Shift: First Shift Final candidates are subject to successful completion of a background check. A drug screen or physical may be required during the post offer process.

Benefits: Medical, dental and vision coverage, with Ohio State paying a significant portion of the cost. Paid time off, including sick and vacation time and 11 holidays. State retirement plan or an alternative retirement plan, both with generous employer contributions. Company Culture The university is an equal opportunity employer, including veterans and disability. At Ohio State, you’ll find work that inspires you. We offer roles and growth opportunities in countless fields and specialties — including a job that’s right for you. Ohio State benefits give you options to take care of what matters most to you — and opportunities to make adjustments as your life and needs change, including: As Buckeyes, we accomplish more together. No matter your role, you’ll be part of creating what people need now: pathways to education, research and health care. Working at Ohio State means you’re part of a team with a strong sense of community and an unwavering commitment to excellence — and, of course, incomparable Buckeye spirit. We bring out the best in people, help each other succeed and learn together. By joining Ohio State, you become part of a top-20 public university with one of America’s leading academic health centers. We’re a team of dedicated colleagues with access to boundless resources that support you.