Principal Scientist, Structural Biology — Drug Discovery

Posted yesterday

genentechMillbrae (CA)

Biochemists and Biophysicists Research and Development in Biotechnology (except Nanobiotechnology)

SENIORITY

Lead

Apply

About the role

Genentech in South San Francisco, CA seeks a Principal Scientist in Structural Biology focused on protein dynamics to join its dynamic Structural Biology group. The role emphasizes integrating cryoEM, X-ray crystallography, and computational methods to understand protein dynamics and ligand binding for drug discovery. You will lead strategy, oversee construct design and structure determination, and mentor teams while driving collaborations across Drug Discovery.

Before you apply

Applying takes about a minute. These four things decide how fast it moves after that.

Your profile is current

It's what we read first. Occupations, seniority and locations matter more than a long history.

Two examples you can talk through

Not a portfolio — just two pieces of work where you can explain the decisions and what you'd change.

A number in mind

What you're on now and what would make you move. We negotiate better when we know both.

Your notice period

Employers plan around it, and it's the question that stalls offers most often.

Once you apply, someone reads it and calls you before anything reaches the employer — usually within two working days.